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A family of metabotropic glutamate receptors.

Affiliations

1. Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
Authors
Tanabe Y¹
(1 author)

ORCIDs linked to this article

Shigemoto R | 0000-0001-8761-9444

Neuron, 01 Jan 1992, 8(1):169-179
https://doi.org/10.1016/0896-6273(92)90118-w PMID: 1309649

Abstract

Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.

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Read article at publisher's site: https://doi.org/10.1016/0896-6273(92)90118-w

References

Articles referenced by this article (39)

A G protein couples serotonin and GABAB receptors to the same channels in hippocampus.
Andrade R, Malenka RC, Nicoll RA
Science, (4781):1261-1265 1986
MED: 2430334
Trans-ACPD depresses synaptic transmission in the hippocampus.
Baskys A, Malenka RC
Eur J Pharmacol, (1):131-132 1991
MED: 1646727
Molecular cloning and functional expression of glutamate receptor subunit genes.
Boulter J, Hollmann M, O'Shea-Greenfield A, Hartley M, Deneris E, Maron C, Heinemann S
Science, (4972):1033-1037 1990
MED: 2168579
Excitatory amino acid receptors and synaptic plasticity.
Collingridge GL, Singer W
Trends Pharmacol Sci, (7):290-296 1990
MED: 2167544
The use of Xenopus oocytes for the study of ion channels.
Dascal N
CRC Crit Rev Biochem, (4):317-387 1987
MED: 2449311
G proteins and dual control of adenylate cyclase.
Gilman AG
Cell, (3):577-579 1984
MED: 6321035
A pertussis toxin-sensitive G protein in hippocampal long-term potentiation.
Goh JW, Pennefather PS
Science, (4907):980-983 1989
MED: 2543072
A new technique for the assay of infectivity of human adenovirus 5 DNA.
Graham FL, van der Eb AJ
Virology, (2):456-467 1973
MED: 4705382
Cloning by functional expression of a member of the glutamate receptor family.
Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S
Nature, (6250):643-648 1989
MED: 2480522
Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Houamed KM, Kuijper JL, Gilbert TL, Haldeman BA, O'Hara PJ, Mulvihill ER, Almers W, Hagen FS
Science, (5010):1318-1321 1991
MED: 1656524

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Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Diseases in OMIM

GLUTAMATE RECEPTOR, METABOTROPIC, 2; GRM2(OMIM - 604099)

Proteins in UniProt (4)

Metabotropic glutamate receptor 1(UniProt - P23385)
Metabotropic glutamate receptor 2(UniProt - P31421)
Metabotropic glutamate receptor 4(UniProt - P31423)
Metabotropic glutamate receptor 3(UniProt - P31422)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/1309649

Nucleotide sequences in ENA (3)

Rat metabotropic glutamate receptor 2 mRNA, primary transcript.(ENA - M92075)
Rat metabotropic glutamate receptor 4 mRNA, primary transcript.(ENA - M92077)
Rat metabotropic glutamate receptor 3 mRNA, primary transcript.(ENA - M92076)

Protein families in InterPro (Showing 5 of 19)

GPCR_3_mtglu_rcpt(InterPro - IPR000162)
GPCR_3_9-Cys_sf(InterPro - IPR038550)
GPCR_3_GABA_rcpt_B2(InterPro - IPR002457)
GPCR3_GABA-B(InterPro - IPR002455)
GPCR_3_mGluR2(InterPro - IPR001458)

Go to all (19) records in InterPro

The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide. (Showing 10 of 10)

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Funding

Funders who supported this work.

Ministry of Education, Culture, Sports, Science and Technology