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Inhaled nitric oxide in persistent pulmonary hypertension of the newborn.

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Affiliations

  • 1. Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
      Authors
    • Roberts JD 1
    (1 author)

ORCIDs linked to this article

Lancet (London, England), 01 Oct 1992, 340(8823):818-819
https://doi.org/10.1016/0140-6736(92)92686-a PMID: 1357245 

A comment on this article appears in "Inhaled nitric oxide for postoperative pulmonary hypertension in patients with congenital heart defects." Lancet. 1992 Dec 19-26;340(8834-8835):1545. A comment on this article appears in "Simple method for monitoring concentration of inhaled nitric oxide." Lancet. 1992 Nov 7;340(8828):1167.

Abstract 

Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preductal oxygen saturation (SpO2); in 5 infants postductal SpO2 and oxygen tensions also increased. Inhalation of NO did not cause systemic hypotension or raise methaemoglobin. These data suggest that low levels of inhaled NO have an important role in the reversal of hypoxaemia due to PPHN.

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Funding 

Funders who supported this work.

NHLBI NIH HHS (1)