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Role of CD8+ T cells in murine experimental allergic encephalomyelitis.

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Affiliations

  • 1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
      Authors
    • Jiang H 1
    (1 author)

Science, 01 May 1992, 256(5060):1213-1215
https://doi.org/10.1126/science.256.5060.1213 PMID: 1375398 

Abstract 

The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease.

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