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Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.

Author information

Affiliations

  • 1. Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
      Authors
    • Gu Y 1
    (1 author)

Science, 01 Oct 2003, 302(5644):445-449
https://doi.org/10.1126/science.1088485 PMID: 14564009 

Abstract 

The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1-/- but not Rac2-/- HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function.

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Read article at publisher's site: https://doi.org/10.1126/science.1088485

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Funding 

Funders who supported this work.

NIDDK NIH HHS (1)