Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Looking backward to move forward: early detection of neurodegenerative disorders.

Author information

Affiliations

  • 1. Department of Neurology and Alzheimer Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
      Authors
    • DeKosky ST 1
    (1 author)

ORCIDs linked to this article

Science, 01 Oct 2003, 302(5646):830-834
https://doi.org/10.1126/science.1090349 PMID: 14593169 

Review

Abstract 

Early detection of neurodegenerative disorders would provide clues to the underlying pathobiology of these diseases and would enable more effective diagnosis and treatment of patients. Recent advances in molecular neuroscience have begun to provide the tools to detect diseases like Alzheimer's disease, Parkinson's disease, and others early in their course and potentially even before the development of clinical manifestations of disease. These genetic, imaging, clinical, and biochemical tools are being validated in a number of studies. Early detection of these slowly progressive diseases offers the promise of presymptomatic diagnosis and, ultimately, of disease-modifying medications for use early in disease and during the presymptomatic period.

Full text links 

Read article at publisher's site: https://doi.org/10.1126/science.1090349

References 

Articles referenced by this article (77)

Show 10 more references (10 of 77)

Citations & impact 

Impact metrics

197
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41876156
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41876156

Article citations

Go to all (197) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.