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Polycomb complexes and silencing mechanisms.

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Affiliations

  • 1. Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
      Authors
    • Lund AH 1
    (1 author)

ORCIDs linked to this article

Current Opinion in Cell Biology, 01 Jun 2004, 16(3):239-246
https://doi.org/10.1016/j.ceb.2004.03.010 PMID: 15145347 

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Abstract 

Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.

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