Divide and conquer: the importance of cell division in regulating B-cell responses.

Tangye SG; Hodgkin PD

doi:10.1111/j.1365-2567.2004.01950.x

Divide and conquer: the importance of cell division in regulating B-cell responses.

Tangye SG ¹,

Hodgkin PD

Affiliations

1. Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2042, NSW, Australia.
Authors
Tangye SG¹
(1 author)

ORCIDs linked to this article

Immunology, 01 Aug 2004, 112(4):509-520
https://doi.org/10.1111/j.1365-2567.2004.01950.x PMID: 15270721

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Abstract

Proliferation is an essential characteristic of clonal selection and is required for the expansion of antigen reactive clones leading to the development of antibody of different isotypes and memory cells. New data for mouse and human B cells point to an important role for division in regulating isotype class and in optimizing development of protective immunity by the regulated entry of cells to the plasma cell lineage.

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Read article at publisher's site: https://doi.org/10.1111/j.1365-2567.2004.01950.x

Read article for free, from open access legal sources, via Unpaywall: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782517

References

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Search life-sciences literature (45,103,589 articles, preprints and more)

Divide and conquer: the importance of cell division in regulating B-cell responses.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Analysis of somatic mutation in five B cell subsets of human tonsil.

Memory B lymphocytes in human tonsil do not express surface IgD.

Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy.

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

Interleukin-6 in human multiple myeloma.

Novel in vitro model for high-rate IgA class switching.

Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.

Generation of memory B cells and plasma cells in vitro.

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.

IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to gamma 1, gamma 3, and gamma 4, but not gamma 2.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1365-2567.2004.01950.x

Article citations

Age-associated changes in innate and adaptive immunity: role of the gut microbiota.

Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture.

Hallmarks of CD8<sup>+</sup> T cell dysfunction are established within hours of tumor antigen encounter before cell division.

Know your enemy or find your friend?-Induction of IgA at mucosal surfaces.

Hematologic disorder-associated Cxcr4 gain-of-function mutation leads to uncontrolled extrafollicular immune response.

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Search life-sciences literature (45,103,589 articles, preprints and more)

Divide and conquer: the importance of cell division in regulating B-cell responses.

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