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Cutting edge: serotonin is a chemotactic factor for eosinophils and functions additively with eotaxin.

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Affiliations

  • 1. La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA.
      Authors
    • Boehme SA 1
    (1 author)

ORCIDs linked to this article

Journal of Immunology (Baltimore, Md. : 1950), 01 Sep 2004, 173(6):3599-3603
https://doi.org/10.4049/jimmunol.173.6.3599 PMID: 15356103 

Abstract 

Elevated levels of serotonin (5-hydroxytryptamine, 5-HT) are observed in the serum of asthmatics. Herein, we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists (including MDL-100907 and cyproheptadine (CYP)) were found to inhibit 5-HT-induced, but not eotaxin-induced migration. Intravital microscopy studies revealed that eosinophils roll in response to 5-HT in venules under conditions of physiological shear stress, which could be blocked by pretreating eosinophils with CYP. OVA-induced pulmonary eosinophilia in wild-type mice was significantly inhibited using CYP alone and maximally in combination with a CCR3 receptor antagonist. Interestingly, OVA-induced pulmonary eosinophilia in eotaxin-knockout (Eot-/-) mice was inhibited by treatment with the 5-HT2A but not CCR3 receptor antagonist. These results suggest that 5-HT is a potent eosinophil-active chemoattractant that can function additively with eotaxin and a dual CCR3/5-HT2A receptor antagonist may be more effective in blocking allergen-induced eosinophil recruitment.

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Read article at publisher's site: https://doi.org/10.4049/jimmunol.173.6.3599

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Funding 

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NIAID NIH HHS (1)