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Nuclear factor-kappaB: the enemy within.

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Affiliations

  • 1. Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
      Authors
    • Aggarwal BB 1
    (1 author)

Cancer Cell, 01 Sep 2004, 6(3):203-208
https://doi.org/10.1016/j.ccr.2004.09.003 PMID: 15380510 

Review

Abstract 

Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-kappaB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer.

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Read article at publisher's site: https://doi.org/10.1016/j.ccr.2004.09.003

Read article for free, from open access legal sources, via Unpaywall: https://www.cell.com/article/S1535610804002442/pdfUnpaywall

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Funding 

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NCI NIH HHS (1)