ATM signaling and genomic stability in response to DNA damage.

Lavin MF; Birrell G; Chen P; Kozlov S; Scott S; Gueven N

doi:10.1016/j.mrfmmm.2004.04.020

Abstract

DNA double strand breaks represent the most threatening lesion to the integrity of the genome in cells exposed to ionizing radiation and radiomimetic chemicals. Those breaks are recognized, signaled to cell cycle checkpoints and repaired by protein complexes. The product of the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) plays a central role in the recognition and signaling of DNA damage. ATM is one of an ever growing number of proteins which when mutated compromise the stability of the genome and predispose to tumour development. Mechanisms for recognising double strand breaks in DNA, maintaining genome stability and minimizing risk of cancer are discussed.

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PIKKc_ATM(InterPro - IPR044107)

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ATM signaling and genomic stability in response to DNA damage.

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Abstract

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References

Radiation-induced DNA damage and its repair.

Biochemistry of DNA lesions.

The effects of γ-radiation in DNA

Role of induced genetic instability in the mutagenic effects of chemicals and radiation.

The mutagenic potential of DNA double-strand break repair.

Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro.

Detecting, signalling and repairing DNA double-strand breaks.

Keynote: past, present, and future aspects of base excision repair

L.H. Thompson, C.L. Limoli, Origin, recognition, signaling and repair of DNA double-strand breaks in mammalian cells, in: K. Caldecott (Ed.), Eukaryotic DNA Damage Surveillance and Repair, Landes Press, 2003, pp. 107–145.

Non-homologous end joining as a mechanism of DNA repair.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

How to use CRISPR/Cas9 in plants: from target site selection to DNA repair.

Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species.

Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women.

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study.

Editorial: Cancer Therapeutics: Targeting DNA Repair Pathways.

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ATM signaling and genomic stability in response to DNA damage.

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The effects of γ-radiation in DNA

Keynote: past, present, and future aspects of base excision repair

L.H. Thompson, C.L. Limoli, Origin, recognition, signaling and repair of DNA double-strand breaks in mammalian cells, in: K. Caldecott (Ed.), Eukaryotic DNA Damage Surveillance and Repair, Landes Press, 2003, pp. 107–145.

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