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Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

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Affiliations

  • 1. Duke University School of Medicine, Durham, NC 27710, USA.
      Authors
    • Haynes BF 1
    (1 author)

ORCIDs linked to this article

Science, 28 Apr 2005, 308(5730):1906-1908
https://doi.org/10.1126/science.1111781 PMID: 15860590 

A comment on this article appears in "Immunology. Close to the edge: neutralizing the HIV-1 envelope." Science. 2005 Jun 24;308(5730):1878-9.

Abstract 

The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.

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Read article at publisher's site: https://doi.org/10.1126/science.1111781

Read article for free, from open access legal sources, via Unpaywall: https://www.science.org/cms/asset/ee7785ee-65a4-4a19-9917-3f7bbc17c13e/pap.pdfUnpaywall

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Funding 

Funders who supported this work.

NIAID NIH HHS (2)