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Professional antigen-presentation function by human gammadelta T Cells.

Author information

Affiliations

  • 1. Institute of Cell Biology, University of Bern, CH-3012, Switzerland.
      Authors
    • Brandes M 1
    (1 author)

ORCIDs linked to this article

Science, 02 Jun 2005, 309(5732):264-268
https://doi.org/10.1126/science.1110267 PMID: 15933162 

A comment on this article appears in "Immunology. Now presenting: gammadelta T cells." Science. 2005 Jul 8;309(5732):252-3.

Abstract 

Human gammadelta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the Vgamma2Vdelta2+-T cell receptor (Vdelta2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve alphabeta T cell proliferation and differentiation. We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.

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Read article at publisher's site: https://doi.org/10.1126/science.1110267

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