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Regulation of histone synthesis and nucleosome assembly.

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Affiliations

  • 1. Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.
      Authors
    • Gunjan A 1
    (1 author)

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Biochimie, 17 Mar 2005, 87(7):625-635
https://doi.org/10.1016/j.biochi.2005.02.008 PMID: 15989979 

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Abstract 

Histone deposition onto nascent DNA is the first step in the process of chromatin assembly during DNA replication. The process of nucleosome assembly represents a daunting task for S-phase cells, partly because cells need to rapidly package nascent DNA into nucleosomes while avoiding the generation of excess histones. Consequently, cells have evolved a number of nucleosome assembly factors and regulatory mechanisms that collectively function to coordinate the rates of histone and DNA synthesis during both normal cell cycle progression and in response to conditions that interfere with DNA replication.

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Read article at publisher's site: https://doi.org/10.1016/j.biochi.2005.02.008

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