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HMG proteins: dynamic players in gene regulation and differentiation.

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  • 1. Università Vita Salute San Raffaele, via Olgettina 58, 20132 Milano, Italy.
      Authors
    • Bianchi ME 1
    (1 author)

ORCIDs linked to this article

Current Opinion in Genetics & Development, 01 Oct 2005, 15(5):496-506
https://doi.org/10.1016/j.gde.2005.08.007 PMID: 16102963 

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Abstract 

Core histones package the genome into nucleosomes and control its accessibility to transcription factors. High mobility group proteins (HMGs) are, after histones, the second most abundant chromatin proteins and exert global genomic functions in establishing active or inactive chromatin domains. It is becoming increasingly clear that they also specifically control the expression of a limited number of genes. Moreover, they contribute to the fine tuning of transcription in response to rapid environmental changes. They do so by interacting with nucleosomes, transcription factors, nucleosome-remodelling machines, and with histone H1.

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Read article at publisher's site: https://doi.org/10.1016/j.gde.2005.08.007

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