Providing one-carbon units for biological methylations: mechanistic studies on serine hydroxymethyltransferase, methylenetetrahydrofolate reductase, and methyltetrahydrofolate-homocysteine methyltransferase

Matthews

Chem Rev 1990

Mechanism of folate requiring enzymes in one-carbon metabolism

Schirch

1998

Conformation and reaction specificity in pyridoxal phosphate enzymes.

Dunathan HC

Proc Natl Acad Sci U S A, (4):712-716 1966

MED: 5219675

Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate.

Tatum CM Jr, Benkovic PA, Benkovic SJ, Potts R, Schleicher E, Floss HG

Biochemistry, (6):1093-1102 1977

MED: 849409

Stereochemistry of reduction of methylenetetrahydrofolate to methyltetrahydrofolate catalyzed by pig liver methylenetetrahydrofolate reductase

Vanoni

J Am Chem Soc 1990

Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.

Trivedi V, Gupta A, Jala VR, Saravanan P, Rao GS, Rao NA, Savithri HS, Subramanya HS

J Biol Chem, (19):17161-17169 2002

MED: 11877399

Purification and characterization of pyridoxal 5'-phosphate dependent serine hydroxymethylase from lamb liver and its action upon beta-phenylserines.

Ulevitch RJ, Kallen RG

Biochemistry, (24):5342-5350 1977

MED: 921936

Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases.

Schirch L, Gross T

J Biol Chem, (21):5651-5655 1968

MED: 5699057

Crystal structure of rabbit cytosolic serine hydroxymethyltransferase at 2.8 A resolution: mechanistic implications.

Scarsdale JN, Kazanina G, Radaev S, Schirch V, Wright HT

Biochemistry, (26):8347-8358 1999

MED: 10387080

Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism.

Szebenyi DM, Musayev FN, di Salvo ML, Safo MK, Schirch V

Biochemistry, (22):6865-6876 2004

MED: 15170323