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Emerging issues in hepatitis C virus-positive liver and kidney transplant recipients.

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Affiliations

  • 1. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
      Authors
    • Bloom RD 1
    (1 author)

ORCIDs linked to this article

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 25 Jul 2006, 6(10):2232-2237
https://doi.org/10.1111/j.1600-6143.2006.01457.x PMID: 16869798 

Review

Abstract 

Hepatitis C virus (HCV) infection is a major health care issue in liver and kidney transplantation. Besides negatively affecting both patient and graft survival, HCV is associated with a heightened risk for new onset diabetes mellitus (NODM). The mechanisms underlying the diabetogenicity of HCV are complex but are likely to involve insulin resistance caused by inhibitory actions of the virus on insulin regulatory pathways in the liver. The resultant glucose dysregulation is an important determinant of increased morbidity and mortality in liver and kidney recipients. This review highlights the concerns for outcomes in HCV-positive liver and kidney transplant patients with particular focus on the interrelationship between hepatitis C and diabetes. Data about the potential role of calcineurin inhibitors, corticosteroids and mycophenolate mofetil in HCV infection and HCV-associated NODM will also be discussed.

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Read article at publisher's site: https://doi.org/10.1111/j.1600-6143.2006.01457.x

Read article for free, from open access legal sources, via Unpaywall: http://www.amjtransplant.org/article/S1600613522028180/pdfUnpaywall

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