Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

The impact of early adverse care on HPA axis development: nonhuman primate models.

Author information

Affiliations

  • 1. Department of Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA 30322, USA.
      Authors
    • Sanchez MM 1
    (1 author)

Hormones and Behavior, 15 Aug 2006, 50(4):623-631
https://doi.org/10.1016/j.yhbeh.2006.06.012 PMID: 16914153 

Review

Abstract 

This review presents supporting evidence that early disruptions in mother-infant relationship in primates, including infant maltreatment, are important risk factors for the development of psychopathology and pathophysiology during childhood and adolescence. Current research in this field is trying to identify important aspects of early adverse experiences such as the timing, frequency, duration, "perceived" intensity of the stressful or traumatic events, the role of social support (e.g., nurturing caregiver) in buffering the deleterious outcomes of early adversity, as well as the role of sex and genetic factors on individual variability in vulnerability. The use of nonhuman primate models of early adverse caregiving is helping to put the pieces of the puzzle together to fully understand the causes and consequences of similar experiences in humans. These models are essential to characterize the time course of biobehavioral alterations throughout development, using prospective, longitudinal studies performed under controlled experimental conditions and using invasive approaches that are unrealistic and unethical when studying human populations.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.yhbeh.2006.06.012

References 

Articles referenced by this article (94)

Show 10 more references (10 of 94)

Citations & impact 

Impact metrics

163
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/15051584
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/15051584

Article citations

Go to all (163) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NCRR NIH HHS (1)

NIMH NIH HHS (3)