Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Herpes simplex virus encephalitis in human UNC-93B deficiency.

Show less

Author information

Affiliations

  • 1. Laboratoire de Génétique Humaine des Maladies Infectieuses, Université de Paris René Descartes, INSERM, U550, Faculté de Médecine Necker, Paris 75015, France.
      Authors
    • Casrouge A 1
    (1 author)

ORCIDs linked to this article

Show all (14)

Science, 14 Sep 2006, 314(5797):308-312
https://doi.org/10.1126/science.1128346 PMID: 16973841 

Abstract 

Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is the most common form of sporadic viral encephalitis in western countries. Its pathogenesis remains unclear, as it affects otherwise healthy patients and only a small minority of HSV-1-infected individuals. Here, we elucidate a genetic etiology for HSE in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-alpha/beta and -lambda antiviral responses. HSE can result from a single-gene immunodeficiency that does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Other severe infectious diseases may also reflect monogenic disorders of immunity.

Full text links 

Read article at publisher's site: https://doi.org/10.1126/science.1128346

Citations & impact 

Impact metrics

469
Citations
Jump to Citations
11
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/102381098
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/102381098

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.1128346

Supporting
Mentioning
Contrasting
18
591
2

Article citations

Go to all (469) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

Medical Research Council (1)