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Resveratrol inhibits firefly luciferase.

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Affiliations

  • 1. Diabetes and Metabolism Disease Area, Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
      Authors
    • Bakhtiarova A 1
    (1 author)

Biochemical and Biophysical Research Communications, 18 Oct 2006, 351(2):481-484
https://doi.org/10.1016/j.bbrc.2006.10.057 PMID: 17064666 

Abstract 

The potential therapeutic value of resveratrol in age-related disease settings including cancer, diabetes, and Alzheimer's has emerged from a rapidly growing body of experimental evidence. Protection from oxidative stress appears to be a common feature of resveratrol that may be mediated through SirT1, though more specific molecular mechanisms by which resveratrol mediates its effects remain unclear. This has prompted an upsurge in cell-based mechanistic studies, often incorporating reporter assays for pathway elucidation in response to resveratrol treatment. Here, we report that resveratrol potently inhibits firefly luciferase with a K(i) value of 2microM, and caution that this confounding element may lead to compromised data interpretation.

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Read article at publisher's site: https://doi.org/10.1016/j.bbrc.2006.10.057

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