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Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants.

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Affiliations

  • 1. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
      Authors
    • Shankaran S 1
    (1 author)

Early Human Development, 01 May 1991, 25(2):135-148
https://doi.org/10.1016/0378-3782(91)90191-5 PMID: 1713544 

Abstract 

Twenty-eight term neonates with severe perinatal asphyxia were referred to a tertiary neonatal intensive care unit (NICU). The morbidity of asphyxia included involvement of the pulmonary (n = 24 infants), central nervous system (n = 22), renal (n = 15), cardiac (n = 14), metabolic (n = 13) and hematologic (n = 10) systems. The majority of neonates had more than three organ systems involved. Twenty-four neonates survived the neonatal course and at NICU discharge all system effects other than the central nervous system had resolved. At 5 years (60 months), 14 children had a normal neurologic examination, 9 had spastic quadriplegia and one had hemiplegia. Nine children had a McCarthy General Cognitive Index (GCI) greater than or equal to 84, 3 had a GCI between 68 and 83 and 12 scored less than 67. Neonatal seizures, renal problems, microcephaly at 3 months, and post-neonatal seizures were associated with an abnormal neurologic outcome or a GCI less than 67. A neurologic examination during the first year of life may reveal whether children with birth asphyxia will be relatively normal at age 5 years or whether they will show considerable delay.

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Read article at publisher's site: https://doi.org/10.1016/0378-3782(91)90191-5

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