Function and biological roles of the Dickkopf family of Wnt modulators.

Niehrs C

doi:10.1038/sj.onc.1210054

Function and biological roles of the Dickkopf family of Wnt modulators.

Niehrs C ¹

Affiliations

1. Department of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany.
Authors
Niehrs C¹
(1 author)

Oncogene, 01 Dec 2006, 25(57):7469-7481
https://doi.org/10.1038/sj.onc.1210054 PMID: 17143291

Review

Abstract

Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted proteins that typically antagonize Wnt/beta-catenin signaling, by inhibiting the Wnt coreceptors Lrp5 and 6. Additionally, Dkks are high affinity ligands for the transmembrane proteins Kremen1 and 2, which also modulate Wnt signaling. Dkks play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.

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References

Articles referenced by this article (126)

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This data has been provided by curated databases and other sources that have cited the article.

Proteins in UniProt (Showing 5 of 13)

Dickkopf-related protein 4(UniProt - Q8VEJ3)
Low-density lipoprotein receptor-related protein 5(UniProt - O75197)
Dickkopf-related protein 2(UniProt - Q9QYZ8)
Low-density lipoprotein receptor-related protein 6(UniProt - O75581)
Dickkopf-related protein 1(UniProt - O94907)

Go to all (13) records in UniProt

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/17143291

Protein families in InterPro (Showing 5 of 8)

Dkk3_N(InterPro - IPR047301)
Dkk1_Cys2(InterPro - IPR047304)
Dkk2_Cys1(InterPro - IPR047303)
Dkk3_Cys2(InterPro - IPR047300)
Dkk4_Cys2(InterPro - IPR047299)

Go to all (8) records in InterPro

The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide. (Showing 10 of 16)

Reactome

https://reactome.org/content/detail/R-HSA-3772470

Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

https://www.xenbase.org/literature/article.do?method=display&articleId=35117

Search life-sciences literature (45,103,589 articles, preprints and more)

Function and biological roles of the Dickkopf family of Wnt modulators.

Affiliations

Authors

Abstract

Full text links

References

Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-Jun-NH2-kinase.

En1 and Wnt7a interact with Dkk1 during limb development in the mouse.

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling.

WNT signals are required for the initiation of hair follicle development.

A colipase fold in the carboxy-terminal domain of the Wnt antagonists--the Dickkopfs.

Segmentation in vertebrates: clock and gradient finally joined.

Wnt3a plays a major role in the segmentation clock controlling somitogenesis.

Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.

High bone mass in mice expressing a mutant LRP5 gene.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1038/sj.onc.1210054

Article citations

ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation.

DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer.

Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

Dynamics of Neurogenic Signals as Biological Switchers of Brain Plasticity.

Newly developed humanized anti-CKAP4 antibody suppresses pancreatic cancer growth by inhibiting DKK1-CKAP4 signaling.

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 13)

Protein families in InterPro (Showing 5 of 8)

Reactome

Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

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Function and biological roles of the Dickkopf family of Wnt modulators.

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Abstract

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Data

Data that cites the article

Proteins in UniProt (Showing 5 of 13)

Protein families in InterPro (Showing 5 of 8)

Reactome

Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

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