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T-cell regulation: with complements from innate immunity.

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  • 1. Washington University School of Medicine, Department of Internal Medicine, Division of Rheumatology, Campus Box 8045, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA.
      Authors
    • Kemper C 1
    (1 author)

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Nature reviews. Immunology, 01 Dec 2006, 7(1):9-18
https://doi.org/10.1038/nri1994 PMID: 17170757 

Review

Abstract 

The complement system was traditionally known as an effector arm of humoral immunity. Today we also recognize it as a main element of the innate immune system. In blood and other body fluids complement is a first line of defence against pathogens, because it becomes fully active within seconds. Active complement fragments attach to the invading pathogen to promote opsonization and lysis, triggering a local inflammatory response. This Review focuses on the evolving role of the complement system in the regulation of T-cell responses, from directing the initiation phase, through driving lineage commitment, to regulating the contraction phase.

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