Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

Lich JD; Williams KL; Moore CB; Arthur JC; Davis BK; Taxman DJ; Ting JP

doi:10.4049/jimmunol.178.3.1256

Abstract

CATERPILLER (NOD, NBD-LRR) proteins are rapidly emerging as important mediators of innate and adaptive immunity. Among these, Monarch-1 operates as a novel attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. However, the molecular mechanisms by which Monarch-1 performs this important function are not well understood. In this report, we show that Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes. This inhibition stems from the ability of Monarch-1 to associate with and induce proteasome-mediated degradation of NF-kappaB inducing kinase. Congruently, silencing Monarch-1 with shRNA enhances the expression of p52-dependent chemokines.

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Gene Ontology Annotation Project

https://www.ebi.ac.uk/QuickGO/annotations?reference=17237370

Proteins in UniProt (4)

RHD domain-containing protein(UniProt - A0A1P8C958)
NACHT, LRR and PYD domains-containing protein 12(UniProt - P59046)
Mitogen-activated protein kinase kinase kinase 14(UniProt - Q99558)
Nuclear factor NF-kappa-B p100 subunit(UniProt - Q00653)

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Grant ID: AI063031
7 publications

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Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

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