Choreography of MAGUKs during T cell activation.

Rincón M; Davis RJ

doi:10.1038/ni0207-126

Choreography of MAGUKs during T cell activation.

Rincón M ,

Davis RJ

ORCIDs linked to this article

Davis RJ | 0000-0002-0130-1652

Nature Immunology, 01 Feb 2007, 8(2):126-127
https://doi.org/10.1038/ni0207-126 PMID: 17242684

This is a comment on "Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors." Nat Immunol. 2007 Feb;8(2):154-61.

Abstract

T cell receptor activation requires the membrane-associated guanylate kinase CARMA1. A new study finds that a second such kinase, Dlgh1, is also required specifically for activation of the alternative p38 kinase pathway.

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References

Articles referenced by this article (15)

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T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion.
Suddason T, Anwar S, Charlaftis N, Gallagher E
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Cited by: 12 articles | PMID: 26774476 | PMCID: PMC4733086
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.
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Cited by: 183 articles | PMID: 25151490 | PMCID: PMC4190666
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.
Javier RT, Rice AP
J Virol, 85(22):11544-11556, 20 Jul 2011
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Cell polarity proteins: common targets for tumorigenic human viruses.
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Oncogene, 27(55):7031-7046, 01 Nov 2008
Cited by: 69 articles | PMID: 19029943 | PMCID: PMC3501650
Review Free full text in Europe PMC

Search life-sciences literature (45,103,589 articles, preprints and more)

Choreography of MAGUKs during T cell activation.

ORCIDs linked to this article

Abstract

Full text links

References

The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells.

JNK and p38 MAP kinases in CD4+ and CD8+ T cells.

Mechanism of p38 MAP kinase activation in vivo.

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.

The activation of lymphocytes is in their CARMA.

Discs large (Dlg1) complexes in lymphocyte activation.

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation.

Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes.

Citations & impact

Impact metrics

Citations of article over time

Article citations

T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion.

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.

Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.

Cell polarity proteins: common targets for tumorigenic human viruses.

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Choreography of MAGUKs during T cell activation.

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