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Retention of protein complex membership by ancient duplicated gene products in budding yeast.

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  • 1. Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada.
      Authors
    • Musso G 1
    (1 author)

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Trends in Genetics : TIG, 10 Apr 2007, 23(6):266-269
https://doi.org/10.1016/j.tig.2007.03.012 PMID: 17428571 

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Abstract 

To investigate functional divergence of gene duplicates, we examined the protein-protein interactions and coexistence in complexes of paralogs resulting from an ancient whole-genome duplication in yeast. Strikingly, half the surveyed paralog pairs were found to be co-clustered in protein complexes, and were more conserved and highly expressed than non-co-clustered paralogs; however, their discordant expression patterns and conservation rates indicate differential regulation of subfunctionalized paralogs. These results highlight the value of protein complex membership in studying functional divergence among gene duplicates.

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