Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Heparan sulphate proteoglycans fine-tune mammalian physiology.

Author information

Affiliations

  • 1. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA.
      Authors
    • Bishop JR 1
    (1 author)

Nature, 01 Apr 2007, 446(7139):1030-1037
https://doi.org/10.1038/nature05817 PMID: 17460664 

Review

Abstract 

Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have demonstrated their importance in development and normal physiology. A recurrent theme is the electrostatic interaction of the heparan sulphate chains with protein ligands, which affects metabolism, transport, information transfer, support and regulation in all organ systems. The importance of these interactions is exemplified by phenotypic studies of mice and humans bearing mutations in the core proteins or the biosynthetic enzymes responsible for assembling the heparan sulphate chains.

Full text links 

Read article at publisher's site: https://doi.org/10.1038/nature05817

References 

Articles referenced by this article (100)

Show 10 more references (10 of 100)

Citations & impact 

Impact metrics

949
Citations
Jump to Citations
1
Data citation
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/14502448
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/14502448

Article citations

Go to all (949) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.