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RNA regulons: coordination of post-transcriptional events.

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Affiliations

  • 1. Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, North Carolina 27710, USA.
      Authors
    • Keene JD 1
    (1 author)

Nature reviews. Genetics, 01 Jul 2007, 8(7):533-543
https://doi.org/10.1038/nrg2111 PMID: 17572691 

Review

Abstract 

Recent findings demonstrate that multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation. These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism. Here I describe several recently discovered examples of RNA operons in budding yeast, fruitfly and mammalian cells, and their potential importance in processes such as immune response, oxidative metabolism, stress response, circadian rhythms and disease. I close by considering the evolutionary wiring and rewiring of these combinatorial post-transcriptional gene-expression networks.

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Read article at publisher's site: https://doi.org/10.1038/nrg2111

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