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Spectrin breakdown products increase with age in telencephalon of mouse brain.

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Affiliations

  • 1. Center for Neurobiology of Learning and Memory, University of California, Irvine 92717-3800.
      Authors
    • Bahr BA 1
    (1 author)

Neuroscience Letters, 01 Oct 1991, 131(2):237-240
https://doi.org/10.1016/0304-3940(91)90622-z PMID: 1762696 

Abstract 

Calcium activated proteolysis of brain spectrin produces characteristic breakdown products (BDPs), the concentrations of which increase markedly in many instances of brain pathology. Results reported here indicate that levels of the BDPs rise with age (3-30 months) in the telencephalon but not in the hindbrain of Balb/c mice. These observations suggest that spectrin breakdown is a pathologic biochemical marker which increases with age in some but not all brain regions.

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Read article at publisher's site: https://doi.org/10.1016/0304-3940(91)90622-z

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Funding 

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NIA NIH HHS (1)