Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with allergic contact dermatitis.

Author information

Affiliations

  • 1. Department of Pharmacology, Faculty of Medicine, Mersin University, Mersin, Turkey.
      Authors
    • Nacak M 1
    (1 author)

ORCIDs linked to this article

Basic & Clinical Pharmacology & Toxicology, 01 Aug 2007, 101(2):101-103
https://doi.org/10.1111/j.1742-7843.2007.00077.x PMID: 17651310 

Abstract 

Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present study was to investigate the possible association between allergic contact dermatitis and insertion/deletion polymorphism of the ACE gene. A total of 90 patients with allergic contact dermatitis and 160 control persons were enrolled in the present study. ACE I/D genotypes were determined by the polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control group (ACE II genotype 30.0% versus 17.5%, P = 0.022; ACE I allele 51.7% versus 39.4%, P = 0.008). Our data suggest that the ACE polymorphism could be a risk factor for patients with allergic contact dermatitis.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/j.1742-7843.2007.00077.x

Read article for free, from open access legal sources, via Unpaywall: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-7843.2007.00077.xUnpaywall

References 

Articles referenced by this article (30)

Show 10 more references (10 of 30)

Citations & impact 

Impact metrics

7
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (7) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.