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Covalent modifications of histones during development and disease pathogenesis.

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Affiliations

  • 1. Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
      Authors
    • Bhaumik SR 1
    (1 author)

Nature Structural & Molecular Biology, 05 Nov 2007, 14(11):1008-1016
https://doi.org/10.1038/nsmb1337 PMID: 17984963 

Review

Abstract 

Covalent modifications of histones are central to the regulation of chromatin dynamics, and, therefore, many biological processes involving chromatin, such as replication, repair, transcription and genome stability, are regulated by chromatin and its modifications. In this review, we discuss the biochemical, molecular and genetic properties of the enzymatic machinery involved in four different types of histone modification: acetylation, ubiquitination, phosphorylation and methylation. We also discuss how perturbation of the activity of this enzymatic machinery can cause developmental defects and disease.

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Read article at publisher's site: https://doi.org/10.1038/nsmb1337

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Funding 

Funders who supported this work.

NCI NIH HHS (1)

NIGMS NIH HHS (2)