Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH; Paull TT

doi:10.1038/sj.onc.1210872

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Lee JH ¹,

Paull TT

Affiliations

1. Department of Molecular Genetics and Microbiology, Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
Authors
Lee JH¹
(1 author)

ORCIDs linked to this article

Oncogene, 01 Dec 2007, 26(56):7741-7748
https://doi.org/10.1038/sj.onc.1210872 PMID: 18066086

Review

Abstract

The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complex in this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells.

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References

Articles referenced by this article (88)

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

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Authors

ORCIDs linked to this article

Abstract

Full text links

References

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage.

Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes.

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response.

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.

FAT: a novel domain in PIK-related kinases.

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

Chk2 activation dependence on Nbs1 after DNA damage.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Phased chromosome-level genome provides insights into the molecular adaptation for migratory lifestyle and population diversity for Pacific saury, Cololabis saira.

Plasma Proteomics of Type 2 Diabetes, Hypertension, and Co-Existing Diabetes/Hypertension in Thai Adults.

Genomic signature for oligometastatic disease in non-small cell lung cancer patients with brain metastases.

Proteomic assessment of SKBR3/HER2+ breast cancer cellular response to Lapatinib and investigational Ipatasertib kinase inhibitors.

DNA Damage Response in Early Breast Cancer: A Phase III Cohort in the Phobos Study.

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Wikipedia

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

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