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Replication potentials of vif variant viruses generated from monkey cell-tropic HIV-1 derivative clones NL-DT5/NL-DT5R.

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Affiliations

  • 1. Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
      Authors
    • Hatcho K 1
    (1 author)

ORCIDs linked to this article

Microbes and Infection, 20 Jun 2008, 10(10-11):1218-1222
https://doi.org/10.1016/j.micinf.2008.06.007 PMID: 18617010 

Abstract 

To obtain monkey-tropic viruses that are more closely related to HIV-1 than the original NL-DT5/NL-DT5R clones, we constructed six vif-chimeric and two site-specific vif-mutant viruses, and examined their growth ability. Different from NL-DT5/NL-DT5R, these viruses did not grow in monkey cells. We monitored the capability of the mutants to antagonize monkey APOBEC3G/F by single-cycle infectivity assays. They counteracted poorly or not at all the action of the APOBEC3G/F. Our results have indicated that the native SIVmac Vif is required to overcome the species barrier against HIV-1.

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Read article at publisher's site: https://doi.org/10.1016/j.micinf.2008.06.007

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Funding 

Funders who supported this work.

Ministry of Education, Culture, Sports, Science and Technology

    Ministry of Health, Labour and Welfare