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Regulation of Schwann cell function by the extracellular matrix.

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Affiliations

  • 1. Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
      Authors
    • Chernousov MA 1
    • Carey DJ 1
    (2 authors)
  • 2. Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York.
      Authors
    • Yu WM 2
    • Chen ZL 2
    • Strickland S 2
    (3 authors)

ORCIDs linked to this article

Glia, 01 Nov 2008, 56(14):1498-1507
https://doi.org/10.1002/glia.20740 PMID: 18803319 

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Abstract 

Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development.

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Read article at publisher's site: https://doi.org/10.1002/glia.20740

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NINDS NIH HHS (3)