NOD-like receptors: role in innate immunity and inflammatory disease.

Chen G; Shaw MH; Kim YG; Nuñez G

doi:10.1146/annurev.pathol.4.110807.092239

NOD-like receptors: role in innate immunity and inflammatory disease.

Chen G ¹,

Shaw MH ,

Kim YG ,

Nuñez G

Affiliations

1. Departments of Pathology and Internal Medicine and the Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Authors
Chen G¹
(1 author)

Annual Review of Pathology, 01 Jan 2009, 4:365-398
https://doi.org/10.1146/annurev.pathol.4.110807.092239 PMID: 18928408

Review

Abstract

The NOD-like receptors (NLRs) are a specialized group of intracellular receptors that represent a key component of the host innate immune system. Since the discovery of the first NLR almost 10 years ago, the study of this special class of microbial sensors has burgeoned; consequently, a better understanding of the mechanism by which these receptors recognize microbes and other danger signals and of how they activate inflammatory signaling pathways has emerged. Moreover, in addition to their primary role in host defense against invading pathogens, their ability to regulate nuclear factor-kappa B (NF-kappaB) signaling, interleukin-1-beta (IL-1beta) production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.

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References

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NOD-like receptors: role in innate immunity and inflammatory disease.

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Authors

Abstract

Full text links

References

Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish.

The genome of the sea urchin Strongylocentrotus purpuratus.

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways.

The NLR gene family: a standard nomenclature.

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production.

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.

TLR signaling.

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Peripheral Blood Mononuclear Cell Transcriptome of Dairy Cows Naturally Infected with Bovine Leukemia Virus.

Mechanism and Application Prospects of NLRC3 Regulating cGAS-STING Pathway in Lung Cancer Immunotherapy.

Activation of NOD1 on tumor-associated macrophages augments CD8<sup>+</sup> T cell-mediated antitumor immunity in hepatocellular carcinoma.

GPR34 senses demyelination to promote neuroinflammation and pathologies.

Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target.

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NOD-like receptors: role in innate immunity and inflammatory disease.

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Funding

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NCI NIH HHS (1)