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Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study.

Author information

Affiliations

  • 1. Department of Radiology, Zhong Da Hospital, School of Clinical Medicine, Southeast University, Nanjing, Jiangsu, China.
      Authors
    • Yao Z 1
    (1 author)

Journal of Affective Disorders, 12 Nov 2008, 115(3):430-438
https://doi.org/10.1016/j.jad.2008.10.013 PMID: 19007997 

Abstract 

Background

Using a newly reported regional homogeneity (ReHo) approach, we were to explore the features of brain activity of patients with major depressive disorder (MDD) in resting state, and further to examine the relationship between abnormal brain activity of depressed patients and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD).

Methods

22 patients with MDD and 22 gender-, age-, and education-matched healthy subjects participated in the fMRI scans.

Results

Limitation

The influence of antidepressant medication to the brain activity of depressed patients was not fully excluded.

Conclusions

Our findings indicated abnormal brain activity was distributed extensively in depressed patients during resting state, and some symptom domains of depression are separately related to specific abnormal patterns of brain activity.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.jad.2008.10.013

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