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Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em.

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Affiliations

  • 1. School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
      Authors
    • Hutchings MI 1
    (1 author)

ORCIDs linked to this article

Trends in Microbiology, 06 Dec 2008, 17(1):13-21
https://doi.org/10.1016/j.tim.2008.10.001 PMID: 19059780 

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Abstract 

Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.

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Read article at publisher's site: https://doi.org/10.1016/j.tim.2008.10.001

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Funding 

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Biotechnology and Biological Sciences Research Council (4)

Medical Research Council (1)