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Symmetric division and expression of its regulatory gene Numb in human cervical squamous carcinoma cells.

Author information

Affiliations

  • 1. Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
      Authors
    • Chen H 1
    (1 author)

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 19 May 2009, 76(3):149-154
https://doi.org/10.1159/000209393 PMID: 19468255 

Abstract 

Objective

To investigate the mode of cell division and Numb expression in cervical squamous cells.

Method

We measured the cleavage angles of cervical squamous epithelia basal cells and Numb protein expression in 50 cases of cervical squamous cell carcinomas (CSCC), 59 cervical intraepithelial neoplasias (CIN) grade II-III, 21 CIN grade I and 48 controls.

Results

We found an increase in horizontal divisions in CIN grade I and a decrease in horizontal divisions in CIN grade II-III. Numb expression had a tendency to be stronger from control to CSCC. In CSCC there was a significantly higher expression of mRNA for the Numb-PRRL isoform but not for the Numb-PRRS isoform.

Conclusion

Our findings suggest that in the initial stage of CSCC, carcinomatous cells may acquire an increase of symmetric division by altering cleavage orientation and proliferation. Expression of Numb protein in Cervical squamous epithelia and an increased expression of Numb-PRRL isoforms may be among the mechanisms involved in the genesis of CSCC.

Full text links 

Read article at publisher's site: https://doi.org/10.1159/000209393

Read article for free, from open access legal sources, via Unpaywall: https://www.karger.com/Article/Pdf/209393Unpaywall

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