Pathogenesis of atopic dermatitis: new developments.

Bieber T; Novak N

doi:10.1007/s11882-009-0041-2

Pathogenesis of atopic dermatitis: new developments.

Bieber T ¹,

Novak N

Affiliations

1. Department of Dermatology and Allergy, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
Authors
Bieber T¹
(1 author)

Current Allergy and Asthma Reports, 01 Jul 2009, 9(4):291-294
https://doi.org/10.1007/s11882-009-0041-2 PMID: 19656476

Review

Abstract

Atopic dermatitis (AD) is a paradigmatic skin disease in which multiple gene-gene and gene-environment interactions play a pivotal role. Although the complex pathophysiologic network of AD explains the large spectrum of risk and trigger factors, it is far from being comprehensively understood. Hence, genetic modifications underlying the dysfunction of the epidermal skin barrier as well as the close interaction of innate and adaptive immune mechanisms were the focus of intensive research studies. This review aims to summarize the most recent findings in this field.

Full text links

Read article at publisher's site: https://doi.org/10.1007/s11882-009-0041-2

References

Articles referenced by this article (40)

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, [...] McLean WH
Nat Genet, (4):441-446 2006
MED: 16550169
Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data.
Baurecht H, Irvine AD, Novak N, Illig T, Buhler B, Ring J, Wagenpfeil S, Weidinger S
J Allergy Clin Immunol, (6):1406-1412 2007
MED: 17980411
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
Weidinger S, Illig T, Baurecht H, Irvine AD, Rodriguez E, Diaz-Lacava A, Klopp N, Wagenpfeil S, Zhao Y, Liao H, Lee SP, Palmer CN, Jenneck C, Maintz L, Hagemann T, Behrendt H, Ring J, Nothen MM, McLean WH, Novak N
J Allergy Clin Immunol, (1):214-219 2006
MED: 16815158
Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis.
Weidinger S, Rodriguez E, Stahl C, Wagenpfeil S, Klopp N, Illig T, Novak N
J Invest Dermatol, (3):724-726 2006
MED: 17096018
Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.
Bisgaard H, Simpson A, Palmer CN, Bonnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A
PLoS Med, (6):e131 2008
MED: 18578563
Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.
Kezic S, Kemperman PM, Koster ES, de Jongh CM, Thio HB, Campbell LE, Irvine AD, McLean WH, McLean IW, Puppels GJ, Caspers PJ
J Invest Dermatol, (8):2117-2119 2008
MED: 18305568
Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study.
de Jongh CM, Khrenova L, Verberk MM, Calkoen F, van Dijk FJ, Voss H, John SM, Kezic S
Br J Dermatol, (3):621-627 2008
MED: 18637008
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.
Novak N, Baurecht H, Schafer T, Rodriguez E, Wagenpfeil S, Klopp N, Heinrich J, Behrendt H, Ring J, Wichmann E, Illig T, Weidinger S
J Invest Dermatol, (6):1430-1435 2007
MED: 18049447
Cytokine modulation of atopic dermatitis filaggrin skin expression.
Howell MD, Kim BE, Gao P, Grant AV, Boguniewicz M, Debenedetto A, Schneider L, Beck LA, Barnes KC, Leung DY
J Allergy Clin Immunol, (1):150-155 2007
MED: 17512043
The immunogenetics of asthma and eczema: a new focus on the epithelium.
Cookson W
Nat Rev Immunol, (12):978-988 2004
MED: 15573132

Show 10 more references (10 of 40)

Citations & impact

Impact metrics

Citations

Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/35538093

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/35538093

Article citations

High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis.
Nene S, Devabattula G, Vambhurkar G, Tryphena KP, Singh PK, Khatri DK, Godugu C, Srivastava S
Drug Deliv Transl Res, 20 Mar 2024
Cited by: 3 articles | PMID: 38509343
Immunological Aspects of Skin Aging in Atopic Dermatitis.
Bocheva GS, Slominski RM, Slominski AT
Int J Mol Sci, 22(11):5729, 27 May 2021
Cited by: 13 articles | PMID: 34072076 | PMCID: PMC8198400
Review
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Fungal Extracellular Vesicles in Pathophysiology.
Garcia-Ceron D, Bleackley MR, Anderson MA
Subcell Biochem, 97:151-177, 01 Jan 2021
Cited by: 8 articles | PMID: 33779917
Childhood atopic dermatitis: current developments, treatment approaches, and future expectations
Gür Çetinkaya P, Şahiner ÜM
Turk J Med Sci, 49(4):963-984, 08 Aug 2019
Cited by: 9 articles | PMID: 31408293 | PMCID: PMC7018348
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean.
Jun M, Wang HY, Lee S, Choi E, Lee H, Choi EH
Allergy Asthma Immunol Res, 10(3):244-252, 01 May 2018
Cited by: 2 articles | PMID: 29676071 | PMCID: PMC5911443
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

Go to all (34) article citations

Search life-sciences literature (45,103,477 articles, preprints and more)

Pathogenesis of atopic dermatitis: new developments.

Affiliations

Authors

Abstract

Full text links

References

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.

Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data.

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.

Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis.

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.

Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study.

Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.

Cytokine modulation of atopic dermatitis filaggrin skin expression.

The immunogenetics of asthma and eczema: a new focus on the epithelium.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis.

Immunological Aspects of Skin Aging in Atopic Dermatitis.

Fungal Extracellular Vesicles in Pathophysiology.

Childhood atopic dermatitis: current developments, treatment approaches, and future expectations

Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean.

Similar Articles

Keratinocytes: innate immune cells in atopic dermatitis.

New insights into the mechanism and management of allergic diseases: atopic dermatitis.

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies.

Partnerships & funding

Similar Articles

Keratinocytes: innate immune cells in atopic dermatitis.
Clin Exp Immunol, 204(3):296-309, 15 Feb 2021

New insights into the mechanism and management of allergic diseases: atopic dermatitis.
Allergy, 64(2):265-275, 01 Feb 2009

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies.
Allergol Int, 66(3):398-403, 02 Jan 2017

Search life-sciences literature (45,103,477 articles, preprints and more)

Pathogenesis of atopic dermatitis: new developments.

Author information

Affiliations

Authors

Abstract

Full text links

References

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Similar Articles

Partnerships & funding