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Plasticity during stroke recovery: from synapse to behaviour.

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  • 1. Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
      Authors
    • Murphy TH 1
    (1 author)

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Nature reviews. Neuroscience, 04 Nov 2009, 10(12):861-872
https://doi.org/10.1038/nrn2735 PMID: 19888284 

Review

Abstract 

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.

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Read article at publisher's site: https://doi.org/10.1038/nrn2735

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Funding 

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Canadian Institutes of Health Research