Tissue factor and cardiovascular disease: quo vadis?

Breitenstein A; Tanner FC; Lüscher TF

doi:10.1253/circj.cj-09-0818

Abstract

The coagulation cascade represents a system of proteases responsible to maintain vascular integrity and to induce rapid clot formation after vessel injury. Tissue factor (TF), the key initiator of the coagulation cascade, binds to factor VIIa and thereby activates factor IX and factor X, resulting in thrombus formation. Different stimuli enhance TF gene expression in endothelial and vascular smooth muscle cells. In addition to these vascular cells, TF has recently been detected in the bloodstream in circulating cells such as leukocytes and platelets, as a component of microparticles, and as a soluble, alternatively spliced form of TF. Various cardiovascular risk factors like hypertension, diabetes, and dyslipidemia, increase levels of TF. In line with this observation, enhanced vascular TF expression occurs during atherogenesis, particularly in patients with acute coronary syndromes. (Circ J 2010; 74: 3 - 12).

Full text links

Read article at publisher's site: https://doi.org/10.1253/circj.cj-09-0818

Read article for free, from open access legal sources, via Unpaywall: https://www.jstage.jst.go.jp/article/circj/74/1/74_CJ-09-0818/_pdf

References

Articles referenced by this article (43)

Title not supplied
AUTHOR UNKNOWN
, (17) 1990
Title not supplied
AUTHOR UNKNOWN
, (9) 1991
Title not supplied
AUTHOR UNKNOWN
, (22) 1992
Title not supplied
AUTHOR UNKNOWN
, (10) 1993
Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation.
Zillmann A, Luther T, Muller I, Kotzsch M, Spannagl M, Kauke T, Oelschlagel U, Zahler S, Engelmann B
Biochem Biophys Res Commun, (2):603-609 2001
MED: 11181090
Comparison of plasma tissue factor levels in unstable and stable angina pectoris.
Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S
Am J Cardiol, (1):22-26 1998
MED: 9462600
Tissue-factor antigen and activity in human coronary atherosclerotic plaques.
Ardissino D, Merlini PA, Ariens R, Coppola R, Bramucci E, Mannucci PM
Lancet, (9054):769-771 1997
MED: 9074577
Overexpression of tissue factor pathway inhibitor in aortic smooth muscle cells inhibits cell migration induced by tissue factor/factor VIIa complex.
Sato Y, Kataoka H, Asada Y, Marutsuka K, Kamikubo Y, Koono M, Sumiyoshi A
Thromb Res, (6):401-406 1999
MED: 10390136
Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1.
Cui MZ, Penn MS, Chisolm GM
J Biol Chem, (46):32795-32802 1999
MED: 10551840
An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression.
Blum S, Issbruker K, Willuweit A, Hehlgans S, Lucerna M, Mechtcheriakova D, Walsh K, von der Ahe D, Hofer E, Clauss M
J Biol Chem, (36):33428-33434 2001
MED: 11445586

Show 10 more references (10 of 43)

Citations & impact

Impact metrics

57

Citations

Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/106515538

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/106515538

Article citations

Expression and role of interleukin-1β and associated biomarkers in deep vein thrombosis.
Pai RZ, Fang Q, Tian G, Zhu B, Ge X
Exp Ther Med, 22(6):1366, 27 Sep 2021
Cited by: 7 articles | PMID: 34659512 | PMCID: PMC8515515
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet.
Yamakage S, Oe Y, Sato E, Okamoto K, Sekimoto A, Kumakura S, Sato H, Yoshida M, Nagasawa T, Miyazaki M, Ito S, Mackman N, Takahashi N
Sci Rep, 11(1):12159, 09 Jun 2021
Cited by: 3 articles | PMID: 34108522 | PMCID: PMC8190319
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Characterization of the inhibition mechanism of a tissuefactor inhibiting single-chain variable fragment: a combined computational approach.
Vermeulen JG, Burt F, van Heerden E, du Preez LL, Meiring M
J Mol Model, 26(4):87, 26 Mar 2020
Cited by: 0 articles | PMID: 32219568
LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.
Kroone C, Vos M, Rademakers T, Kuijpers M, Hoogenboezem M, van Buul J, Heemskerk JWM, Ruf W, van Hylckama Vlieg A, Versteeg HH, Goumans MJ, de Vries CJM, Kurakula K, INVENT Consortium
Haematologica, 105(6):1677-1685, 29 Aug 2019
Cited by: 2 articles | PMID: 31467128 | PMCID: PMC7271603
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice.
Yang Y, Hu L, Wang C, Yang X, Song L, Jiang C, Li Y, Li T, Liu WT, Feng J
Biomed Res Int, 2019:5347804, 10 Jul 2019
Cited by: 6 articles | PMID: 31380428 | PMCID: PMC6652066
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

Go to all (57) article citations

Search life-sciences literature (45,103,589 articles, preprints and more)

Tissue factor and cardiovascular disease: quo vadis?

Affiliations

Authors

Abstract

Full text links

References

Title not supplied

Title not supplied

Title not supplied

Title not supplied

Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation.

Comparison of plasma tissue factor levels in unstable and stable angina pectoris.

Tissue-factor antigen and activity in human coronary atherosclerotic plaques.

Overexpression of tissue factor pathway inhibitor in aortic smooth muscle cells inhibits cell migration induced by tissue factor/factor VIIa complex.

Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1.

An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Expression and role of interleukin-1β and associated biomarkers in deep vein thrombosis.

Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet.

Characterization of the inhibition mechanism of a tissuefactor inhibiting single-chain variable fragment: a combined computational approach.

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis.

p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice.

Similar Articles

Tissue factor: beyond coagulation in the cardiovascular system.

Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications.

[Biology and physiopathology of tissue factor and its relevance for cardiovascular diseases].

Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention.

Partnerships & funding

Similar Articles

Tissue factor: beyond coagulation in the cardiovascular system.
Clin Sci (Lond), 118(3):159-172, 26 Oct 2009

Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications.
Circulation, 113(5):722-731, 01 Feb 2006

[Biology and physiopathology of tissue factor and its relevance for cardiovascular diseases].
Ital Heart J Suppl, 4(7):559-568, 01 Jul 2003

Tissue factor in cardiovascular disease pathophysiology and pharmacological intervention.
Adv Pharmacol, 59:259-292, 01 Jan 2010

Search life-sciences literature (45,103,589 articles, preprints and more)

Tissue factor and cardiovascular disease: quo vadis?

Author information

Affiliations

Authors

Abstract

Full text links

References

Title not supplied

Title not supplied

Title not supplied

Title not supplied

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Similar Articles

Partnerships & funding