RNA immunization can protect mice against foot-and-mouth disease virus.

Pulido MR; Sobrino F; Borrego B; Sáiz M

doi:10.1016/j.antiviral.2009.12.005

RNA immunization can protect mice against foot-and-mouth disease virus.

Affiliations

1. Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Cantoblanco, 28049 Madrid, Spain.<>
Authors
Pulido MR¹
(1 author)

ORCIDs linked to this article

Antiviral Research, 18 Dec 2009, 85(3):556-558
https://doi.org/10.1016/j.antiviral.2009.12.005 PMID: 20005905

Abstract

In previous work we have reported the immunization of swine using in vitro-transcribed foot-and-mouth disease virus (FMDV) RNA. With the aim of testing whether RNA-induced immunization can mediate protection against viral infection, a group of Swiss adult mice was inoculated with FMDV infectious transcripts. In most inoculated animals viral RNA was detected in serum at 48-72h postinoculation. A group of the RNA-inoculated mice (11 out of 19) developed significant titers of neutralizing antibodies against FMDV. Among those animals that were successfully challenged with infectious virus (15 out of 19), three out of the eight animals immunized upon RNA inoculation were protected, as infectious virus could not be isolated from sera but specific anti-FMDV antibodies could be readily detected. These results suggest the potential of the inoculation of genetically engineered FMDV RNA for virulence and protection assays in the murine model and allow to explore the suitability of RNA-based FMDV vaccination in natural host animals.

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References

Articles referenced by this article (32)

Recovery of infectious foot-and-mouth disease virus from suckling mice after direct inoculation with in vitro-transcribed RNA.
Baranowski E, Molina N, Nunez JI, Sobrino F, Saiz M
J Virol, (20):11290-11295 2003
MED: 14512578
Multiple virulence determinants of foot-and-mouth disease virus in cell culture.
Baranowski E, Sevilla N, Verdaguer N, Ruiz-Jarabo CM, Beck E, Domingo E
J Virol, (8):6362-6372 1998
MED: 9658076
DNA immunization with 2C FMDV non-structural protein reveals the presence of an immunodominant CD8+, CTL epitope for Balb/c mice.
Barfoed AM, Rodriguez F, Therrien D, Borrego B, Sobrino F, Kamstrup S
Antiviral Res, (3):178-189 2006
MED: 16890298
Modern inactivated foot-and-mouth disease (FMD) vaccines: historical background and key elements in production and use
Barteling
2004
Development of DNA vaccines for foot-and-mouth disease, evaluation of vaccines encoding replicating and non-replicating nucleic acids in swine.
Beard C, Ward G, Rieder E, Chinsangaram J, Grubman MJ, Mason PW
J Biotechnol, (2-3):243-249 1999
MED: 10486933
Genome organisation, translation and replication of FMDV RNA
Belsham
2004
Immune response to foot-and-mouth disease virus in a murine experimental model: effective thymus-independent primary and secondary reaction.
Borca MV, Fernandez FM, Sadir AM, Braun M, Schudel AA
Immunology, (2):261-267 1986
MED: 3490436
DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses.
Borrego B, Fernandez-Pacheco P, Ganges L, Domenech N, Fernandez-Borges N, Sobrino F, Rodriguez F
Vaccine, (18):3889-3899 2006
MED: 16563575
Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase.
Cedillo-Barron L, Foster-Cuevas M, Belsham GJ, Lefevre F, Parkhouse RME
J Gen Virol, (Pt 7):1713-1724 2001
MED: 11413383
T cell-dependent induction of antibody against foot-and-mouth disease virus in a mouse model.
Collen T, Pullen L, Doel TR
J Gen Virol, 395-403 1989
MED: 2543745

Show 10 more references (10 of 32)

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Search life-sciences literature (45,103,589 articles, preprints and more)

RNA immunization can protect mice against foot-and-mouth disease virus.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Recovery of infectious foot-and-mouth disease virus from suckling mice after direct inoculation with in vitro-transcribed RNA.

Multiple virulence determinants of foot-and-mouth disease virus in cell culture.

DNA immunization with 2C FMDV non-structural protein reveals the presence of an immunodominant CD8+, CTL epitope for Balb/c mice.

Modern inactivated foot-and-mouth disease (FMD) vaccines: historical background and key elements in production and use

Development of DNA vaccines for foot-and-mouth disease, evaluation of vaccines encoding replicating and non-replicating nucleic acids in swine.

Genome organisation, translation and replication of FMDV RNA

Immune response to foot-and-mouth disease virus in a murine experimental model: effective thymus-independent primary and secondary reaction.

DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses.

Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase.

T cell-dependent induction of antibody against foot-and-mouth disease virus in a mouse model.

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Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.antiviral.2009.12.005

Article citations

The combination of vaccines and adjuvants to prevent the occurrence of high incidence of infectious diseases in bovine.

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development.

mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases.

Vaccines for COVID-19: The current state of play.

Advances in mRNA Vaccines for Infectious Diseases.

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Search life-sciences literature (45,103,589 articles, preprints and more)

RNA immunization can protect mice against foot-and-mouth disease virus.

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Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Modern inactivated foot-and-mouth disease (FMD) vaccines: historical background and key elements in production and use

Genome organisation, translation and replication of FMDV RNA

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