Lipid rafts as a membrane-organizing principle.

Lingwood D; Simons K

doi:10.1126/science.1174621

Abstract

Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally segregate its constituents. This capability is based on dynamic liquid-liquid immiscibility and underlies the raft concept of membrane subcompartmentalization. Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and trafficking. Here we review the evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity.

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Lipid rafts as a membrane-organizing principle.

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Lipid rafts: elusive or illusive?

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.

Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin.

Detergent resistance as a tool in membrane research.

Lipid rafts: at a crossroad between cell biology and physics.

Membrane lipids: where they are and how they behave.

Functional rafts in cell membranes.

The fluid mosaic model of the structure of cell membranes.

Title not supplied

Phase equilibria in the phosphatidylcholine-cholesterol system.

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Impact metrics

Citations of article over time

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Article citations

Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects.

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.

Biochemical Pathways Delivering Distinct Glycosphingolipid Patterns in MDA-MB-231 and MCF-7 Breast Cancer Cells.

Rotational dynamics of a disk in a thin film of weakly nematic fluid subject to linear friction.

Towards a unifying model for B-cell receptor triggering.

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