HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

Trono D; Van Lint C; Rouzioux C; Verdin E; Barré-Sinoussi F; Chun TW; Chomont N

doi:10.1126/science.1191047

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

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1. School of Life Sciences and Frontiers-in-Genetics Program, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Authors
Trono D¹
(1 author)

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Science, 01 Jul 2010, 329(5988):174-180
https://doi.org/10.1126/science.1191047 PMID: 20616270

Review

Abstract

HIV infection can persist in spite of efficacious antiretroviral therapies. Although incomplete inhibition of viral replication may contribute to this phenomenon, this is largely due to the early establishment of a stable reservoir of latently infected cells. Thus, life-long antiviral therapy may be needed to control HIV. Such therapy is prone to drug resistance and cumulative side effects and is an unbearable financial burden for regions of the world hit hardest by the epidemic. This review discusses our current understanding of HIV persistence and the limitations of potential approaches to eradicate the virus and accordingly pleads for a joint multidisciplinary effort toward two highly related goals: the development of an HIV prophylactic vaccine and the achievement of long-term drug-free remissions in HIV-infected individuals.

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Search life-sciences literature (45,103,589 articles, preprints and more)

HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Current status and challenges of antiretroviral research and therapy.

Redefining chronic viral infection.

Towards an understanding of the molecular basis of herpes simplex virus latency.

Immunobiology and pathogenesis of viral hepatitis.

HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir.

Direct Observation of Vortex Dynamics in Superconducting Films with Regular Arrays of Defects

Relationship between human immunodeficiency virus type 1 (HIV-1)-specific memory cytotoxic T lymphocytes and virus load after recent HIV-1 seroconversion.

Decay characteristics of HIV-1-infected compartments during combination therapy.

Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy.

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication.

Cell-cell communication and initial population composition shape the structure of potato spindle tuber viroid quasispecies.

gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity.

PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent.

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation.

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HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

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