Advances in understanding cancer genomes through second-generation sequencing.

Meyerson M; Gabriel S; Getz G

doi:10.1038/nrg2841

Advances in understanding cancer genomes through second-generation sequencing.

Meyerson M ¹,

Gabriel S ,

Getz G

Affiliations

1. Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Authors
Meyerson M¹
(1 author)

ORCIDs linked to this article

Meyerson M | 0000-0002-9133-8108

Nature reviews. Genetics, 01 Oct 2010, 11(10):685-696
https://doi.org/10.1038/nrg2841 PMID: 20847746

Review

Abstract

Cancers are caused by the accumulation of genomic alterations. Therefore, analyses of cancer genome sequences and structures provide insights for understanding cancer biology, diagnosis and therapy. The application of second-generation DNA sequencing technologies (also known as next-generation sequencing) - through whole-genome, whole-exome and whole-transcriptome approaches - is allowing substantial advances in cancer genomics. These methods are facilitating an increase in the efficiency and resolution of detection of each of the principal types of somatic cancer genome alterations, including nucleotide substitutions, small insertions and deletions, copy number alterations, chromosomal rearrangements and microbial infections. This Review focuses on the methodological considerations for characterizing somatic genome alterations in cancer and the future prospects for these approaches.

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Read article at publisher's site: https://doi.org/10.1038/nrg2841

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Funders who supported this work.

NCI NIH HHS (2)

Grant ID: U24CA143867
20 publications
Grant ID: U24CA143845
25 publications

NHGRI NIH HHS (1)

Grant ID: U54HG003067
85 publications

Search life-sciences literature (45,103,589 articles, preprints and more)

Advances in understanding cancer genomes through second-generation sequencing.

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ORCIDs linked to this article

Abstract

Full text links

References

Accurate whole human genome sequencing using reversible terminator chemistry.

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays.

Genome sequencing in microfabricated high-density picolitre reactors.

Accurate multiplex polony sequencing of an evolved bacterial genome.

The complete genome of an individual by massively parallel DNA sequencing.

Transcriptome sequencing to detect gene fusions in cancer.

Chimeric transcript discovery by paired-end transcriptome sequencing.

Exome sequencing identifies the cause of a mendelian disorder.

Targeted capture and massively parallel sequencing of 12 human exomes.

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

How Have Massively Parallel Sequencing Technologies Furthered Our Understanding of Oncogenesis and Cancer Progression?

Integrating frontiers: a holistic, quantum and evolutionary approach to conquering cancer through systems biology and multidisciplinary synergy.

Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing.

Advances in next-generation sequencing for relapsed pediatric acute lymphoblastic leukemia: current insights and future directions.

A Bayesian framework to study tumor subclone-specific expression by combining bulk DNA and single-cell RNA sequencing data.

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Wikipedia (3)

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Advances in understanding cancer genomes through second-generation sequencing.

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