Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.

Lollini PL; De Giovanni C; Nicoletti G; Bontadini A; Tazzari PL; Landuzzi L; Scotlandi K; Nanni P

doi:10.1007/bf00117794

Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.

Affiliations

1. Istituto di Cancerologia, Università di Bologna, Italy.
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Lollini PL¹
(1 author)

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Clinical & Experimental Metastasis, 01 Mar 1990, 8(2):215-224
https://doi.org/10.1007/bf00117794 PMID: 2107993

Abstract

The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.

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References

Articles referenced by this article (21)

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Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

The differential expression of H-2K versus H-2D antigens, distinguishing high-metastatic from low-metastatic clones, is correlated with the immunogenic properties of the tumor cells.

MHC imbalance and metastatic spread in Lewis lung carcinoma clones.

Influence of H-2K transfection on susceptibility of fibrosarcoma tumor cells to natural killer (NK) cells.

Efficient DNA-mediated transfer of selectable genes and unselected sequences into differentiated and undifferentiated mouse melanoma clones.

Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.

Synergistic defense system by cooperative natural effectors against metastasis of B16 melanoma cells in H-2-associated control: different behavior of H-2+ and H-2- cells in metastatic processes.

Lollini, P.-L., De Giovanni, C., Del Re, B., Nicoletti, G., Prodi, G., and Nanni, P., 1987, Interferon-mediated enhancement of metastasis. Are MHC antigens involved? Clinical and Experimental Metastasis, 5, 277-287.

Interferon-induced alterations in metastatic capacity, class-1 antigen expression and natural killer cell sensitivity of melanoma cells.

Impaired H-2 expression in B16 melanoma variants.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS).

In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.

Anti-tumor activity of CpG-ODN aerosol in mouse lung metastases.

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.

Microenvironment of the murine mammary carcinoma 4T1: endogenous IFN-gamma affects tumor phenotype, growth, and metastasis.

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Search life-sciences literature (45,105,671 articles, preprints and more)

Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.

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References

Lollini, P.-L., De Giovanni, C., Del Re, B., Nicoletti, G., Prodi, G., and Nanni, P., 1987, Interferon-mediated enhancement of metastasis. Are MHC antigens involved? Clinical and Experimental Metastasis, 5, 277-287.

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