Type I interferon production induced by RIG-I-like receptors.

Onomoto K; Onoguchi K; Takahasi K; Fujita T

doi:10.1089/jir.2010.0117

Type I interferon production induced by RIG-I-like receptors.

Affiliations

1. Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Authors
Onomoto K¹
(1 author)

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, 01 Dec 2010, 30(12):875-881
https://doi.org/10.1089/jir.2010.0117 PMID: 21121861

Review

Abstract

Type I interferon (IFN) is produced in a variety of tissues in the body in response to viral infections. Recent studies have revealed that cytoplasmic receptors for viral (nonself) RNA are responsible for triggering IFN production. Different viruses activate different sensors. Numerous signaling adaptors are reported to participate in the regulation of the IFN gene's activation. In this paper, the role of free polyubiquitine chains in the activation of retinoic acid inducible gene I (RIG-I)-like receptors and the involvement of mitochondria as a signaling platform in the modulation of RIG-I-like receptor signaling is reviewed.

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Read article at publisher's site: https://doi.org/10.1089/jir.2010.0117

References

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Search life-sciences literature (45,103,589 articles, preprints and more)

Type I interferon production induced by RIG-I-like receptors.

Affiliations

Authors

Abstract

Full text links

References

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway.

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

Inhibition of cell-free protein synthesis by pppA2'p5'A2'p5'A: a novel oligonucleotide synthesized by interferon-treated L cell extracts.

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.

Does Toll-like receptor 3 play a biological role in virus infections?

Citations & impact

Impact metrics

Citations of article over time

Article citations

High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response.

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis.

Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patients.

Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes.

Identification of Natural Molecular Determinants of Ross River Virus Type I Interferon Modulation.

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Type I interferon production induced by RIG-I-like receptors.

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