B-lymphocyte effector functions in health and disease.

DiLillo DJ; Horikawa M; Tedder TF

doi:10.1007/s12026-010-8189-3

B-lymphocyte effector functions in health and disease.

DiLillo DJ ¹,

Horikawa M ,

Tedder TF

Affiliations

1. Department of Immunology, Duke University Medical Center, Room 353 Jones Building, Research Drive, Box 3010, Durham, NC 27710, USA.
Authors
DiLillo DJ¹
(1 author)

ORCIDs linked to this article

DiLillo DJ | 0000-0003-2653-2913

Immunologic Research, 01 Apr 2011, 49(1-3):281-292
https://doi.org/10.1007/s12026-010-8189-3 PMID: 21125343

Review

Abstract

B-lymphocytes have traditionally been thought to contribute to immunity and autoimmune disease through terminal differentiation into plasma cells that secrete antibody. However, studies in mice and recent clinical studies have demonstrated that genetically altered B-cell function and B-cell-targeted therapies can significantly affect autoimmune diseases that were predominantly thought to be T-cell-mediated. B-cell depletion in mouse models of disease has also led to the identification of alternative B-cell effector functions that regulate normal immune responses and autoimmune disease. This review highlights multiple B-cell effector mechanisms, including the promotion of cellular immunity, the negative regulation of immune responses, and the production of pathogenic antibodies.

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Search life-sciences literature (45,103,589 articles, preprints and more)

B-lymphocyte effector functions in health and disease.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.

Competence and competition: the challenge of becoming a long-lived plasma cell.

Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice.

Identifying regulatory B cells (B10 cells) that produce IL-10 in mice.

Distinct profiles of human B cell effector cytokines: a role in immune regulation?

B lymphocytes differentially influence acute and chronic allograft rejection in mice.

Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia.

A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.

Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo.

Lifetime of plasma cells in the bone marrow.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/s12026-010-8189-3

Article citations

B-cells in pulmonary arterial hypertension: friend, foe or bystander?

Sterile inflammation in liver transplantation.

Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments.

Susceptibility identification for seasonal influenza A/H3N2 based on baseline blood transcriptome.

Impact of Antigen Presentation Mechanisms on Immune Response in Autoimmune Hepatitis.

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B-lymphocyte effector functions in health and disease.

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