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Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity.

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Affiliations

  • 1. U.S. Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD 20910, USA.
      Authors
    • Epstein JE 1
    (1 author)

ORCIDs linked to this article

Science, 08 Sep 2011, 334(6055):475-480
https://doi.org/10.1126/science.1211548 PMID: 21903775 

A comment on this article appears in "First clinical trial of purified, irradiated malaria sporozoites in humans." Expert Rev Vaccines. 2012 Jan;11(1):31-3. A comment on this article appears in "Immunology. Another shot at a malaria vaccine." Science. 2011 Oct 28;334(6055):460-1.

Abstract 

Our goal is to develop a vaccine that sustainably prevents Plasmodium falciparum (Pf) malaria in ≥80% of recipients. Pf sporozoites (PfSPZ) administered by mosquito bites are the only immunogens shown to induce such protection in humans. Such protection is thought to be mediated by CD8(+) T cells in the liver that secrete interferon-γ (IFN-γ). We report that purified irradiated PfSPZ administered to 80 volunteers by needle inoculation in the skin was safe, but suboptimally immunogenic and protective. Animal studies demonstrated that intravenous immunization was critical for inducing a high frequency of PfSPZ-specific CD8(+), IFN-γ-producing T cells in the liver (nonhuman primates, mice) and conferring protection (mice). Our results suggest that intravenous administration of this vaccine will lead to the prevention of infection with Pf malaria.

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Read article at publisher's site: https://doi.org/10.1126/science.1211548

Read article for free, from open access legal sources, via Unpaywall: https://www.science.org/cms/asset/c33a997e-504e-4d64-bcf5-80f84d406eff/pap.pdfUnpaywall

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Funding 

Funders who supported this work.

Howard Hughes Medical Institute

    NIAID NIH HHS (3)