Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family.

Author information

Affiliations

  • 1. Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden.
      Authors
    • Ernfors P 1
    (1 author)

Neuron, 01 Oct 1990, 5(4):511-526
https://doi.org/10.1016/0896-6273(90)90090-3 PMID: 2206535 

Abstract 

Cells expressing mRNA for hippocampus-derived neurotrophic factor (HDNF/NT-3) or brain-derived neurotrophic factor (BDNF) were identified by in situ hybridization. In the rat brain, HDNF mRNA was predominantly found in pyramidal neurons in CA1 and CA2 of the hippocampus. Lower levels of HDNF mRNA were found in granular neurons of the dentate gyrus and in neurons of the taenia tecta and induseum griseum. BDNF mRNA-expressing cells were more widely distributed in the rat brain, with high levels in neurons of CA2, CA3, and the hilar region of the dentate gyrus, in the external and internal pyramidal layers of the cerebral cortex, in the claustrum, and in one brainstem structure. Lower levels were seen in CA1 and in the granular layer of the hippocampus, in the taenia tecta, and in the mammillary complex. In peripheral tissues, HDNF mRNA was found in glomerular cells in the kidney, secretory cells in the male rat submandibular gland, and epithelial cells in secondary and tertiary follicles in the ovary. Cells expressing BDNF mRNA were found in the dorsal root ganglia, where neurons of various sizes were labeled.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/0896-6273(90)90090-3

References 

Articles referenced by this article (66)

Show 10 more references (10 of 66)

Citations & impact 

Impact metrics

583
Citations
Jump to Citations
7
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41514799
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41514799

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0896-6273(90)90090-3

Supporting
Mentioning
Contrasting
30
337
1

Article citations

Go to all (583) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIA NIH HHS (1)

NINDS NIH HHS (1)