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Metformin and cancer stem cells: old drug, new targets.

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Affiliations

  • 1. Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
      Authors
    • Bednar F 1
    (1 author)

ORCIDs linked to this article

Cancer Prevention Research (Philadelphia, Pa.), 01 Mar 2012, 5(3):351-354
https://doi.org/10.1158/1940-6207.capr-12-0026 PMID: 22389436 

This is a comment on "Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells." Cancer Prev Res (Phila). 2012 Mar;5(3):355-64.

Abstract 

In this issue of the journal, Bao and colleagues report (beginning on page 355) that the antidiabetic drug metformin targets pancreatic cancer stem cells through, at least partially, the modulation of miRNA expression and subsequent regulation of stem cell renewal and signaling factors. In this Perspective, we briefly discuss the cancer stem cell hypothesis, its clinical relevance, and how targeting the mTOR pathway may yield an avenue for disrupting the cancer stem cell compartment and thus yield long-term therapeutic benefit in multiple cancers.

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Read article at publisher's site: https://doi.org/10.1158/1940-6207.capr-12-0026

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